She also had words for the married men as well.
During yesterday's episode, Williams went in on both the men who step out of their marriages and the women they do it with while addressing Ayesha Curry's recent comments about being married to a famous athlete.
While appearing on "Red Table Talk," Curry opened up about some of the aggressive women who come up to her basketball star husband, hitting on him right in front of her.
Williams showed a clip of Curry explaining how a woman jumped in their car to get a photo with Steph, while he was with her and their daughter Riley. "The woman opens the car door, sticks her body in the car and is just like, 'Oh, let me see.' And I'm like, 'No, no, get out of the car,'" she explained. "And she goes, 'Oh, honey, you know what you signed up for.'"
"There are a lot of women with no respect for a marriage," Williams said in reaction to the conversation, before a dramatic pause. "You know what I'm saying? A lot of women who know your man is married and will have the nerve to be right up under him, right under your nose."
"For you lonely girls who can't keep their hands off other people's men, there's a hot place in hell for you," Williams then said, a comment which was met with applause from the studio audience.
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She didn't only blame the women though, adding, "In all cases, I feel as though, a woman's only gonna do that if the man lets her."
"Most of the time if a woman is doing something like that, she's got nothing to lose," she said. "If you bite back, man, then you lose."
Williams and her husband of almost 22 years, Kevin Hunter, split back in April after Hunter's alleged mistress, Sharina Hudson, gave birth.